Read Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering)

Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering)

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Description:This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering). To get started finding Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering), you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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ISBN: 1108846408

Description: This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering). To get started finding Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering), you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering)

Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-up (Cambridge Series in Chemical Engineering)

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